Cyclophosphamide versus cytarabine mobilization of hematopoietic stem cells with G-CSF stimulation in myeloma patients subjected to autologous stem cell transplantation

[摘要] The aim of our study was to compare different regimes of hematopoietic stem cell (HSC) mobilization, i.e., cyclophosphamide combined with granulocyte colony-stimulating factor (Cy/G-CSF), versus cytarabine with G-CSF (Ara-C/G-CSF). Efficiency and toxicity of these treatment regimens were assessed. Achievement of partial remission of the disease was sufficient for successful mobilization. CD34+ cell numbers in the blood showed a significant correlation with total number of CD34+ yielded by apheresis on the same day. When comparing the two groups of mobilization we have revealed that the patients treated with AraC + G-CSF yielded higher amounts of CD34+ cells in peripheral blood on the first apheresis day. Moreover, lesser occurrence of toxicity was revealed in group of patients treated with AraC-G-CSF.

[学科分类] 肿瘤学

[关键词] Hematopoietic stem cell mobilization;hematopoietic stem cell transplantation;multiple myeloma.