Synergistic Positive Feedback Mechanisms Underlying Seizure Initiation

[摘要] Investigations into seizure initiation, in recent years, have focused almost entirely upon alterations of interneuronal function, chloride homeostasis, and extracellular potassium levels. In contrast, little attention has been directed toward a possible role of dendritic plateau potentials in the actual ictogenic transition, despite a substantial literature dating back 40 years regarding its importance generally in epilepsy. Here, we argue that an increase in dendritic excitability, coordinated across the population of pyramidal cells, is a key stage in ictogenesis.

[学科分类] 精神健康和精神病学

[关键词] pyramidal cell;dendritic plateau potential;inhibition;chloride;potassium;ictogenesis