Isolation and structural identification of a new T1-conotoxin with unique disulfide connectivities derived from Conus bandanus

[摘要] Background: Conopeptides are neuropharmacological peptides derived from the venomous salivary glands of cone snails. Among 29 superfamilies based on conserved signal sequences, T-superfamily conotoxins, which belong to the smallest group, include four different frameworks that contain four cysteines denominated I, V, X and XVI. In this work, the primary structure and the cysteine connectivity of novel conotoxin of Conus bandanus were determined by tandem mass spectrometry using collision-induced dissociation.

[学科分类] 药理学

[关键词] T1-subfamily conotoxin;Conus bandanus;Bn5a;Disulfide connectivity;Cone snail venom