Analgesic and side effects of intravenous recombinant Phα1β

[摘要] Background: Intrathecal injection of voltage-sensitive calcium channel blocker peptide toxins exerts analgesic effect in several animal models of pain. Upon intrathecal administration, recombinant Phα1β exerts the same analgesic effects as the those of the native toxin. However, from a clinical perspective, the intrathecal administration limits the use of anesthetic drugs in patients. Therefore, this study aimed to investigate the possible antinociceptive effect of intravenous recombinant Phα1β in rat models of neuropathic pain, as well as its side effects on motor, cardiac (heart rate and blood pressure), and biochemical parameters.

[学科分类] 药理学

[关键词] Recombinant Phα1β;Analgesia;Neuropathic pain;Intravenous drug delivery system;Side effects;Cardiac function;Motor activity;Biochemicals