Recombinant antibodies against Iranian cobra venom as a new emerging therapy by phage display technology

[摘要] Background: The production of antivenom from immunized animals is an established treatment for snakebites; however, antibody phage display technology may have the capacity to delivery results more quickly and with a better match to local need. Naja oxiana , the Iranian cobra, is a medically important species, responsible for a significant number of deaths annually. This study was designed as proof of principle to determine whether recombinant antibodies with the capacity to neutralize cobra venom could be isolated by phage display.

[学科分类] 药理学

[关键词] Antibody phage display;Venom;Antivenom;Purification