Identification and characterization of the first endogenous phospholipase A 2 inhibitor from a non-venomous tropical snake, Boa constrictor (Serpentes: Boidae)

[摘要] Background: Endogenous phospholipase A 2 inhibitors from snake blood (sbPLIs) have been isolated from several species around the world, with the primary function of self-protection against the action of toxic phospholipases A 2. In American snakes, sbPLIs were solely described in pit vipers, in which the natural protection role is justified. In this study, we described a sbPLI in Boa constrictor (popularly known as jiboia ), a non-venomous snake species from America.

[学科分类] 药理学

[关键词] Phospholipase A 2 inhibitor;Phospholipase A 2;Boidae;Snakes;Rattlesnake venom