Design, synthesis, and evaluation of Bothrops venom serine protease peptidic inhibitors

[摘要] Background: In Central and South America, snakebite envenomation is mainly caused by Bothrops spp. snakes, whose venoms feature significant biochemical richness, including serine proteases. The available bothropic antivenoms are efficient in avoiding fatalities, but do not completely neutralize venom serine proteases, which are co-responsible for some disorders observed during envenomation.

[学科分类] 药理学

[关键词] Peptides;Snake venom;Serine protease;Disease;Hemostasis