Kinetic and toxicological effects of synthesized palladium(II) complex on snake venom (Bungarus sindanus ) acetylcholinesterase

[摘要] Background: The venom of the krait ( Bungarus sindanus ), an Elapidae snake, is highly toxic to humans and contains a great amount of acetylcholinesterase (AChE). The enzyme AChE provokes the hydrolysis of substrate acetylcholine (ACh) in the nervous system and terminates nerve impulse. Different inhibitors inactivate AChE and lead to ACh accumulation and disrupted neurotransmission.

[学科分类] 药理学

[关键词] Palladium (II) complex;Snake venom;Acetylcholinesterase;Inhibition;Kinetics