Proteomics, toxicity and antivenom neutralization of Sri Lankan and Indian Russell’s viper ( Daboia russelii ) venoms

[摘要] Background: The western Russell’s viper ( Daboia russelii ) is widely distributed in South Asia, and geographical venom variation is anticipated among distant populations. Antivenoms used for Russell’s viper envenomation are, however, raised typically against snakes from Southern India. The present study investigated and compared the venom proteomes of D. russelii from Sri Lanka (DrSL) and India (DrI), the immunorecognition of Indian VINS Polyvalent Antivenom (VPAV) and its efficacy in neutralizing the venom toxicity.

[学科分类] 药理学

[关键词] Geographical variation;Venomics;Antivenomics;Antivenom potency