Polymorphisms in Genes Related to Cervical Cancer in A Brazilian Population: A Case-Control Study

[摘要] Cervical cancer (CC) is the fourth most common cancer in women, with approximately 528,000 new cases in the world each year, 80% of them in developing countries [1]. It is well recognized that persistent infection of human papillomavirus (HPV) is the main cause of precursor lesions that progress to CC, but only a small proportion of these HPV infected women develop the disease. In this sense, polymorphisms in human genes have also been associated with CC [2]. Genome-wide studies investigated the association of human single nucleotide polymorphisms (SNPs) with HPV persistent infection, progression to cervical intraepithelial neoplasia (CIN) and CC in Latin American women [3, 4]. More than seven thousand SNPs were investigated in genes related to immune response, DNA repair, viral replication and entry into the host cell. Association to persistent HPV progression to CIN and CC was observed with SNPs in genes of DNA repair (EXO1, CYBA, FANCA, XRCC1, GTF2H4, DUT, FLJ35220, and DMC1), immune response (IRF) and virus entry into the cell (SULF1 and OAS3) [3, 4].