Microbial inhibitors active against Plasmodium falciparum dihydroorotate dehydrogenase derived from an Indonesian soil fungus, Talaromyces pinophilus BioMCC-f.T.3979

[摘要] An Indonesian soil fungus, Talaromyces pinophilus BioMCC-f.T.3979 was cultured to find novel scaffolds of Plasmodium falciparum dihydroorotate dehydrogenase ( Pf DHODH) inhibitors. We obtained altenusin ( 1 ), which inhibits Pf DHODH, with an IC 50 value of 5.9 μM, along with other metabolites: mitorubrinol ( 2 ) and mitorubrinic acid ( 3 ). Compounds 1 and 2 inhibited Pf DHODH but displayed no activity against the human orthologue. They also inhibited P. falciparum 3D7 cell growth in vitro . Compound 3 showed little Pf DHODH inhibitory activity or cell growth inhibitory activity.

[学科分类] 微生物学和免疫学

[关键词] dihydroorotate dehydrogenase;malaria;Plasmodium falciparum;Talaromyces pinophilus