Gentisyl alcohol and homogentisic acid: Plasmodium falciparum dihydroorotate dehydrogenase inhibitors isolated from fungi

[摘要] Two Indonesian fungi Aspergillus assiutensis BioMCC-f.T.7495 and Penicillium pedernalense BioMCC-f.T.5350 along with a Japanese fungus Hypomyces pseudocorticiicola FKI-9008 have been found to produce gentisyl alcohol ( 1 ), which inhibits Plasmodium falciparum dihydroorotate dehydrogenase ( Pf DHODH) with an IC 50 value of 3.4 μM. Another Indonesian fungus, Penicillium citrinum BioMCC-f.T.6730, produced an analog of 1 , homogentisic acid ( 4 ), which also inhibits Pf DHODH with an IC 50 value of 47.6 μM.

[学科分类] 微生物学和免疫学

[关键词] dihydroorotate dehydrogenase;inhibitor;malaria;Plasmodium falciparum