Mesenchymal stem cells are more effective than captopril in reverting cisplatin-induced nephropathy

[摘要] Cisplatin is a powerful anticancer drug but its nephrotoxic effects limit its clinical use. We aimed to evaluate the effect of mesenchymal stem cells (MSCs) injection or of captopril to counteract the cisplatin-induction of nephropathy. MSCs isolation, preparation and tracking, transforming growth factor-β (TGF-β) and interleukin-10 (IL-10) expressions, kidney function tests, oxidative stress state, and histological examinations were done. Cisplatininduced nephropathy was indicated biochemically and confirmed histopathologically. MSCs treatment showed normal kidney architecture, and significantly decreased oxidative stress and TGF-β while increased IL-10 and improved kidney function tests. Rats treated with cisplatin + captopril showed noticeable kidney histopathological changes. Superior positive impact of MSCs in amelioration of cisplatin-induced nephropathy via their ability to motivate functional and structural renal repair is evidenced.

[学科分类] 仪器

[关键词] Histopathology;IL-10;Minerals;Nephropathy;Oxidative stress;PCR;Repair;TGF-β