Serum Irisin Level Is Positively Associated with Bone Mineral Density in Patients on Maintenance Hemodialysis

[摘要] Background . Irisin is a circulating hormone-like myokine that plays an important role in bone metabolism. We performed a cross-sectional study to investigate whether serum irisin levels correlated with bone mineral density (BMD) in patients on maintenance hemodialysis (MHD). Methods . Blood samples were obtained from 80 patients on MHD, and serum irisin concentrations were determined using a commercially available enzyme-linked immunosorbent assay. BMD was measured by dual-energy X-ray absorptiometry of the L2–L4 vertebrae. Results . In the study cohort, 10 (12.5%) and 19 (23.8%) patients had osteoporosis and osteopenia, respectively, and 51 (63.75%) patients had normal BMD. Lumbar T-score was negatively associated with body height ( ), body weight ( ), body mass index (BMI, ), and serum irisin ( ) and was positively associated with advanced age ( ), female sex ( ), alkaline phosphatase (ALP, ), urea reduction rate ( ), and fractional clearance index for urea ( ). Multivariable forward stepwise linear regression analysis revealed that high serum logarithmically transformed irisin (log-irisin, β  = 0.450, adjusted R 2 change = 0.258; ), female sex ( β  = −0.353, adjusted R 2 change = 0.134; ), and serum ALP level ( β  = −0.176, adjusted R 2 change = 0.022; ) were significantly and independently associated with lumbar BMD in patients on MHD. Conclusions . In addition to female sex and serum ALP level, serum irisin level was positively associated with lumbar BMD in patients on MHD.

[学科分类] 自然科学（综合）