Occurrence of bla NDM-1 in a Clinical Isolate of Acinetobacter lwoffii in Japan: Comparison of bla NDM-1 -Harboring Plasmids between A. lwoffii and A. pittii Originated from a Hospital Sink

[摘要] Acinetobacter spp. are recognized to be significantnosocomial pathogens because of their capability fordeveloping resistance to a wide range of antimicrobialsby acquiring resistance mechanisms very quickly (1,2).Thus, they serve as potential hospital reservoirs forresistance genes/elements,which are subsequentlyspread among other clinically relevant Acinetobacterspecies, such as A. baumannii， A. nosocomialis，andA. pittii. The acquisition of carbapenem resistanceby Acinetobacter spp. is most commonly due totheir production of carbapenemases (e.g.，OXA-type carbapenemase) and, less frequently, metallo-B-lactamases.The New Delhi metallo-B-lactamases(NDM), the rapid dissemination of which is causingworldwide concern，are the most prevalent of themetallo-B-lactamases in Acinetobacter spp., occurringpredominantly in A. baumannii (3,4). Herein,wereport the discovery of a clinical isolate of A.lwoffii inJapan that harbored both the blaNDM-1 gene and a novelblaoxA-915 carbapenemase gene. We also demonstratethat the NDM-1-encoding plasmid harbored by this A.lwoffi isolate obtained from an inpatient analyzed inthis study exhibited significant sequence identity withthat harbored by a previously described A.pittii strainthat had been isolated one year earlier from a sink in thesame hospital ward (5).

[学科分类] 传染病学