Biotransformation of a biosynthetic intermediate mimic of nonactin by Streptomyces griseus

[摘要] A mimic of a plausible biosynthetic intermediate of bisho­mononactic acid, one of the monomers of macrotetrolide antibiotics (polynactin), was synthesized as a thiol ester. FAB-MS analysis showed that fermentation of polynactin producing Streptomyces griseus with the compound, afforded the unnatural polynactins containing bishomononactic acid(s).

[学科分类] 内科医学

[关键词] antibiotics;bishomononactic acid;biotransformation;polynactin;Streptomyces griseus;synthesis