Efficient synthesis of thieno[2,3-d]pyrimidin-4(3H)-ones by a sequential aza-Wittig reaction/base catalyzed cyclization

[摘要] 7-Benzyl-5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3- d ]pyrimidin-4(3 H )-ones were synthesized by base catalyzed reactions of nucleophilic reagents (aliphatic amines, alcohols or phenols) with carbodiimides 4 , which in turn were obtained by the aza-Wittig reaction of iminophosphoranes 3 with aromatic isocyanates.

[学科分类] 内科医学

[关键词] aza-Wittig reaction;carbodiimide;iminophosphorane;thieno[2;3-d]pyrimidin-4(3H)-one