Synthesis and biological activity of some novel N-dichloroacetyl-2,3-dihydrobenzoxazole derivatives

[摘要] A facile synthetic route was developed to N -dichloroacetyl-2,3-dihydrobenzoxazole derivatives 3 by cycloaddition of 2-amino-phenol ( 1 ) with dichloromethane and acylation of the resultant intermediate 2,3-dihydrobenzoxazole 2 with dichloroacetyl chloride. The structures of the compounds were characterized by IR, 1 H NMR, and 13 C NMR spectroscopy and elemental analysis. The preliminary biological tests showed that products 3 could protect maize against injury caused by acetochlor to some extent.

[学科分类] 内科医学

[关键词] bioactivity;N-dichloroacetyl-2;3-dihydroben­zoxazole;synthesis