The utilization of 2-aminoprop-1-ene-1,1,3-tricarbonitrile as a precursor to quinoline, furan and thiophene derivatives with antitumor activities

[摘要] The condensation reaction of 2-aminoprop-1-ene-1,1,3-tricarbonitrile ( 1 ) with 2-acetyl-furan ( 2 ) afforded 2-amino-4-(furan-2-yl)penta-1,3-diene-1,1,3-tricarbonitrile ( 3 ). The latter compound underwent a series of heterocyclization reactions to give quinoline, furan, pyrazole and thiophene derivatives. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) were recorded. Three of the synthesized compounds, namely 4 , 5d and 12 showed high inhibitory effects.

[学科分类] 内科医学

[关键词] antitumor activity;furan;pyrazole;quinoline;thiophene