Synthesis and structure of a novel tridentate chiral-NHC ligand precursor

[摘要] A novel tridentate chiral imidazolium hexafluorophosphate, a precursor for N -heterocyclic carbene (NHC) ligand, was synthesized from (S)-proline in five steps in 24% overall yield. The compound was characterized by NMR and elemental analysis. Its molecular structure was determined by X-ray diffraction analysis. This chiral compound has two stereogenic centers which are within two chelating side chains and its specific rotation is -19.6°.

[学科分类] 内科医学

[关键词] chiral;imidazolium salt;NHC ligand;(S)-proline;X-ray structure