Thiazolo[4,5-d]pyrimidines: synthesis and antibacterial evaluation

[摘要] The reaction of 4-amino-5-bromo-2-chloro-6-methylpyrimidine ( 1 ) with carbon disulfide in the presence of KOH in DMF quantitatively gave 5-chloro-7-methylthiazolo[4,5- d ] pyrimidine-2 (3 H )-thione ( 2 ) which was then alkylated at the sulfur atom with various alkyl halides in the presence of Et 3 N in acetonitrile to give alkylthio derivatives 3 . The substitution of the chlorine atom in 3 with morpholine was also investigated. The synthesized compounds were subjected to antibacterial evaluations.

[学科分类] 内科医学

[关键词] antibacterial evaluation;heterocyclization;thiazolo[4;5-d]pyrimidine