Synthesis and transformations of novel formyl-substituted quinolines

[摘要] In the present contribution we study the reaction of 4-hydroxy- and 4-chloro-2-methylquinolines with Vilsmeier-Haack reagent. The reaction of 2-(4-chloroquinolin-2-yl)-3-hydroxy­acrylaldehydes thus obtained with nucleophiles leads to potentially bioactive quinolines that contain pyrazole and piperidine groups.

[学科分类] 内科医学

[关键词] malonic dialdehyde;quinoline;Vilsmeier-Haack reagent;2-(4-Chloroquinolin-2-yl)-3-hydroxyacrylaldehyde