Synthesis of 1,2,3 triazole-linked benzimidazole through a copper-catalyzed click reaction

[摘要] An efficient method has been developed for the synthesis of 1,2,3 triazole-linked benzimidazole through a copper-catalyzed click reaction in ethanol at 50°C. A broad range of aromatic azides were successfully reacted with n -propynylated benzimidazole via copper-catalyzed azide-alkyne cycloaddition reactions in the absence of a ligand. This method offers many advantages including short reaction times, low cost, and simple purification procedures.

[学科分类] 内科医学

[关键词] 1;2;3-triazole;Benzimidazole;Click reaction