Synthesis and fungicidal activities of perfluoropropan-2-yl-based novel quinoline derivatives

[摘要] A series of novel perfluoropropan-2-yl-based quinoline derivatives was designed and synthesized utilizing tebufloquin as the lead compound. The structures of all the newly synthesized compounds were confirmed by spectroscopic data 1 HNMR, MS and elemental analysis. The results of bioassay indicated that these compounds exhibited potent fungicidal activities against Erysiphe graminis . Especially, compound 8c displayed excellent activity with EC 50 value at 1.48 mg / L, which was better than that of the commercialized fungicide --- tebufloquin. The structure-activity relationship for these new compounds was also discussed.

[学科分类] 内科医学

[关键词] perfluoropropan-2-yl-based quinoline derivatives;synthesis;fungicidal activity;structure-activity relationship