Synthesis and spectral characteristics of N-(1-([1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-ylamino)-2,2,2-trichloroethyl)carboxamides

[摘要] Based on readily available N -(2,2,2-trichloro-1-hydroxyethyl)carboxamides, N -(2,2,2-trichloro-1-(3-(3-mercapto-4 H -1,2,4-triazol-4-yl)thioureido)ethyl) carboxamides, dehydrosulfurization–under the influence of excess HgO–led to the formation of N -(1-([1,2,4] triazolo[3,4- b ][1,3,4]thiadiazol-6-ylamino)-2,2,2-trichloroethyl)carboxamides. The reaction was carried out in boiling glacial acetic acid for 1-1.5 hours. The cyclization products were obtained in 42-62% yields and easily isolated from the reaction mixture. The structure of all synthesized compounds was confirmed by complex spectral studies.

[学科分类] 内科医学

[关键词] dehydrosulfurization;[1;2;4]triazolo[3;4-b] [1;3;4]thiadiazole;thioureas;N-amidoalkylated