Diastereoselective synthesis of dispiro[indoline-3,1′-cyclobutane-2′,3″-indolines] via visible light catalyzed cyclodimerization of 3-phenacylideneoxindoles

[摘要] A simple synthetic protocol was developed for the efficient synthesis of functionalized dispiro[indoline-3,1′-cyclobutane-2′,3″-indolines] with high diastereoselectivity. The reaction proceeds by cyclodimerization reaction of 3-phenacylideneoxindoles in the presence of a catalytic amount of photosensitizer Ru(bpy 3 )Cl 2 and visible light.

[学科分类] 内科医学

[关键词] cyclodimerization;diastereoselectivity;dispirocyclobutane-3;3′-bisoxindole;spirooxindole;visible light