Regioselective 1,4-conjugate aza-Michael addition of dienones with benzotriazole

[摘要] The regioselective 1,4-conjugate aza-Michael addition of dienones with benzotriazole catalyzed by potassium acetate is described. A series of 3-(benzotriazol-1-yl)-1,5-diarylpent-4-en-1-ones were efficiently synthesized under mild conditions. This protocol has advantages of transition-metal free catalyst, high yield and high regioselectivity.

[学科分类] 内科医学

[关键词] aza-Michael addition;benzotriazole;dienone;regioselectivity;synthesis