C1-Substituted N-tert-butoxycarbonyl-5-syn-tert-butyldimethylsilyloxymethyl-2-azabicyclo[2.1.1]hexanes as conformationally constrained β-amino acid precursors

[摘要] Regioselective introduction and transformation of substituents at the C 1 carbon of N - tert -butoxycarbonyl-5- syn - tert -butyldimethylsilyloxymethyl-2-azabicyclo[2.1.1]hexane ( 7 ) is described. These azabicycles are precursors to conformationally constrained β-amino acids with potential to form oligomers with definite secondary structures. Selected examples of these precursors are converted into their corresponding amino acid derivatives.

[学科分类] 内科医学

[关键词] β-amino acid;constrained;foldamers;pyrrolidine-3-carboxylic acids