Synthesis of the spiroacetal fragments of spirofungins A and B, antibiotics isolated from Streptomyces violaceusniger Tü 4113
[摘要] The spiroacetal [C(9)–C(20)] fragments of spirofungins A and B, antibiotics isolated from Streptomyces violaceusniger Tü 4113, were prepared from a known bromo alcohol derived from ( S )-citronellal, using thermodynamically controlled iodolactonization and spiroacetalization as the key steps.
[发布日期] [发布机构]
[效力级别] [学科分类] 内科医学
[关键词] acetylide;antibiotics;iodolactonization;selenolactonization;spiroacetalization;spirofungins A and B;Streptomyces violaceusniger Tü 4113;synthesis [时效性]
