Baker’s yeast catalyzed one-pot synthesis of bioactive 2-[benzylidene(or pyrazol-4-ylmethylene)hydrazono]-1,3-thiazolidin-4-one-5-yl-acetic acids

[摘要] An efficient and simple one-pot protocol has been developed for synthesis of substituted derivatives of 2-hydrazono-4-thiazolidinone-5-acetic acids 4a–j and 6a–g by cyclocondensation of aryl/pyrazolyl aldehyde, thiosemicarbazide and maleic anhydride in acetonitrile in the presence of readily available whole cell biocatalyst, baker’s yeast ( Saccharomyces cerevisiae ). The reaction is enhanced by ultrasonication.

[学科分类] 内科医学

[关键词] baker’s yeast;2-hydrazono-4-thiazolidinon-5-yl-acetic acids;one-pot multicomponent reaction;ultrasonication