Synthesis, antimicrobial activity and anti-biofilm activity of novel tetrazole derivatives

[摘要] In the development of antimicrobial agents, we designed and synthesized novel tetrazole derivatives. The structures of compounds 6a–f and 7a–f were characterized by IR, 1 H NMR, 13 C NMR, MS and elemental analysis. These compounds were tested for their antimicrobial activity against a series of strains Staphylococcus aureus, Bacillus subtilis, Escherichia coli , and Pseudomonas aeruginosa and for antifungal activity against the strains Candida albicans, Candida glabrata , and Candida tropicalis . Compounds 6e , 6f , 7a , and 7f exhibit potent antimicrobial activities compared to the reference drugs streptomycin and miconazole. Tetrazole derivatives 7a–f also inhibit biofilm formation and compound 7f exhibits best anti-biofilm activity with a biofilm inhibitory concentration (BIC) as low as 0.9 μ m .

[学科分类] 内科医学

[关键词] antibiofilm;antimicrobial;flavones;tetrazole