Microwave-assisted synthesis of bis(N-substituted thiazol-2-amine) derivatives and their biological activities

[摘要] New 4,4′-(4,6-dimethoxy-1,3-phenylene)-bis( N -substituted thiazol-2-amine) derivatives 5a–j were synthesized from 1,1′-(4,6-dimethoxy-1,3-phenylene)-bis(2-bromoethanone) 3 and substituted thioureas 4a–j under conventional and microwave irradiation conditions. All products were subjected to in vitro antibacterial and anti-TB evaluation. Some of the compounds exhibit good activities against Bacillus subtilis (+ve), Escherichia coli (−ve) strains and Mycobacterium tuberculosis H37Rv.

[学科分类] 内科医学

[关键词] anti-TB;antibacterial;microwave irradiation;thiazole