Ultrasound mediated synthesis of dihydropyrano[3,2-d][1,3]dioxin-7-carbonitrile derivatives in H2O/EtOH medium

[摘要] A one-pot cyclocondensation of 1,3-dioxane-5-one ( 1 ) with malononitrile and aromatic aldehydes in aqueous sodium hydroxide under ultrasonic irradiation furnishes a series of pyrano[3,2- d ][1,3]dioxin derivatives 3 . Reactions are completed after a few minutes and the precipitated products are purified by simple crystallization from ethanol. The reaction with ethyl cyanoacetate instead of malononitrile gives the respective analogous products in high yields.

[学科分类] 内科医学

[关键词] aqueous;1;3-dioxane-5-one;multicomponent reaction;one-pot synthesis;ultrasonication