A simple approach to fused pyrido[2,3-d]pyrimidines incorporating khellinone and trimethoxyphenyl moieties as new scaffolds for antibacterial and antifungal agents

[摘要] 2-Amino-3-cyanopyridine is a simple precursor for the synthesis of analogues of Egyptian natural products visnagin and khellin. Fused pyrido[2,3- d ]pyrimidines were prepared under mild reaction conditions. The detailed syntheses and spectroscopic data of the synthesised compounds are reported. Some isolated compounds show antibacterial and antifungal activity.

[学科分类] 内科医学

[关键词] 2-amino-3-cyanopyridine;antibacterial activity;antifungal activity;khellinone;N-pyrazolyl derivatives;pyrido[2;3-d]pyrimidine;trimethoxyphenyl