Synthesis of new heterocyclic compounds containing benzimidazole moiety as inhibitors of breast cancer cell growth

[摘要] A series of new benzimidazole derivatives, namely 2-acylbenzimidazoles 2–9 , a dihydroquinoxaline 10 , a benzoxazine 11 , quinolines 13–15 and fused 1,2,4-triazines 17–24 were synthesized. Structure elucidation of the compounds was conducted using IR, 1 H NMR, 13 C NMR, mass spectral data and elemental analysis. These products were evaluated for in vitro antitumor activity against MCF7 cell line (human breast cancer). Compounds 13–15 and 24 manifested significant antitumor activity.

[学科分类] 内科医学

[关键词] antitumor;benzimidazoles;benzoxazines;quinolines;quinoxalines;1;2;4-triazines;synthesis