Synthesis of H4 pantetheine adducts for histone acetyltransferase inhibition

[摘要] Site-specific modifications of peptides provide a powerful tool for design of chemical probes and enzyme inhibitors. A convenient synthesis method was developed and used to produce H4K16-pantetheine bisubstrate analogs which could be employed as inhibitors of histone acetyltransferases in vivo and in vitro .

[学科分类] 内科医学

[关键词] bisubstrate inhibitor;histone acetyltransferases (HATs);H4;pantetheine