Highly efficient [3+3] cycloaddition reactions of in situ generated aza-oxyallyl cation with nitrones

[摘要] An efficient protocol was developed for the synthesis of 1,2,4-oxadiazinan-5-one derivatives via [3+3] cycloaddition of in situ generated aza-oxyallyl cations with nitrones. This method provides high yields of the heterocyclic products, excellent regioselectivity and broad substrate scope.

[学科分类] 内科医学

[关键词] aza-oxyallyl cations;cycloaddition;heterocycles;metal free;nitrones