An efficient cascade synthesis of substituted 6,9-dihydro-1H-pyrazolo[3,4-f]quinoline- 8-carbonitriles

[摘要] The synthesis of pyrazolo[3,4- f ]quinoline-8-carbonitriles 4a–h and 6a–k involves the reaction of an aromatic aldehyde, 1 H -indazol-6-amine and 3-(1 H -indol-3-yl)-3-oxopropanenitrile or 3-oxo-3-arylpropanenitrile in ethanol under mild conditions.

[学科分类] 内科医学

[关键词] catalyst-free;multi-component domino reactions;pyrazoloquinoline