Kaempferol attenuates spinal cord injury by interfering inflammatory and oxidative stress by targeting the p53 protein: a molecular docking analysis

[摘要] Background Kaempferol (KMF) is a flavone reported to have anti-oxidant and anti-inflammatory activity. Objective The present study screened the effect of KMF in the animal model of spinal cord injury (SCI). Results KMF caused a significant inhibition of spinal cord injury mediated oxidative stress and also suppressed the inflammatory reactions. The treatment of KMF also inhibited the levels of p53, TGF-β1 and COX-2 whereas a significant elevation in Bcl-2/Bax ratio was observed after the rats were treated with KMF. The in silico docking analysis suggested potential binding of KMF having lower energy with p53 confirming the potential target of KMF. Conclusion The treatment of KMF exerted neuroprotective effect by improving the anti-oxidant status and inflammatory response. The significant spinal cord injury protective effect of KMF in rats was attributed by targeting p53 and Bcl-2/Bax ratio.

[关键词] Spinal cord injury;Kaempferol;P53;Oxidative stress;Inflammatory response