Selective stimulation of rat sciatic nerve using an array of mm-size magnetic coils: a simulation study

[摘要] This work proposes and computationally investigate the use of magnetic neural stimulation as an alternative to electrical stimulation to achieve selective activation of rat sciatic nerve. In particular, they assess the effectiveness of an array of small coils to obtain selective neural stimulation, as compared to a single coil. Specifically, an array of four mm-sized coils is used to stimulate rat sciatic nerve, targeting the regions of fascicles that are associated with different muscles of the leg. To evaluate the selectivity of activation, a three-dimensional heterogeneous multi-resolution nerve model is implemented using the impedance method for the computation of the magnetic and electric fields in the nerve. The performance metric ‘selectivity index’ is defined that measures the recruitment of the targeted region compared to other non-targeted regions of the nerve. The selectivity index takes values between −1 (least selective) and 1 (most selective). For each targeted region, a selectivity index of 0.75 or better is predicted for the proposed array configuration. The results suggest that an array of coils can provide superior spatial control of the electric field induced in the neural tissue compared to traditional extraneural electrode arrays, thus opening the possibility to applications where selective neurostimulation is of interest.

[学科分类] 肠胃与肝脏病学

[关键词] biological tissues;physiological models;neurophysiology;neuromuscular stimulation;bioelectric potentials;muscle;biomagnetism;bioelectric phenomena;biomedical electrodes;targeted region;nontargeted regions;selectivity index;array configuration;traditional extraneural electrode arrays;selective neurostimulation;selective stimulation;rat sciatic nerve;mm-size magnetic coils;magnetic neural stimulation;electrical stimulation;selective activation;selective neural stimulation;single coil;three-dimensional heterogeneous multiresolution nerve model;magnetic fields;electric fields;performance metric