An Energy efficient application specific integrated circuit for electrocardiogram feature detection and its potential for ambulatory cardiovascular disease detection

[摘要] A novel algorithm based on forward search is developed for real-time electrocardiogram (ECG) signal processing and implemented in application specific integrated circuit (ASIC) for QRS complex related cardiovascular disease diagnosis. The authors have evaluated their algorithm using MIT-BIH database and achieve sensitivity of 99.86% and specificity of 99.93% for QRS complex peak detection. In this Letter, Physionet PTB diagnostic ECG database is used for QRS complex related disease detection. An ASIC for cardiovascular disease detection is fabricated using 130-nm CMOS high-speed process technology. The area of the ASIC is 0.5 mm 2 . The power dissipation is 1.73 μW at the operating frequency of 1 kHz with a supply voltage of 0.6 V. The output from the ASIC is fed to their Android application that generates diagnostic report and can be sent to a cardiologist through email. Their ASIC result shows average failed detection rate of 0.16% for six leads data of 290 patients in PTB diagnostic ECG database. They also have implemented a low-leakage version of their ASIC. The ASIC dissipates only 45 pJ with a supply voltage of 0.9 V. Their proposed ASIC is most suitable for energy efficient telemetry cardiovascular disease detection system.

[学科分类] 肠胃与肝脏病学

[关键词] electrocardiography;diseases;patient diagnosis;bioelectric potentials;medical computing;electrocardiogram;ECG feature detection;ambulatory cardiovascular disease detection;real-time ECG signal processing;application specific integrated circuit;cardiovascular disease diagnosis;MIT-BIH database;QRS complex peak detection;Physionet PTB diagnostic ECG database;CMOS high-speed process technology;Android application;energy efficient ASIC;telemetry cardiovascular disease detection system;power 1.73 muW;frequency 1 kHz;voltage 0.6 V