Re: Abnormally Low Hemoglobin A1c as Harbinger of Hemoglobinopathy

[摘要] Dear Editor, we found that the article titled, “Low Hemoglobin A1c as Harbinger of Hemoglobinopathy,” very interesting.1 We would like to share ideas on this report. Regarding the abnormal low hemoglobin A1c level, there are many possible cause. It might relate to malnutrition or too strict diabetes contrl.2–3 In the present case,1 the problem is due to background personal illness of the patient. In fact, the aberration of hemoglobin A1c level due to hemoglobinopathy is a common problem in any settings with high prevalence of hemoglobin disorder.4 The interference of abnormal hemoglobin on laboratory analysis is confirmed and quantification of hemoglobin A1c level is usually altered in various ways, either aberrant low or high.4–5 For monitoring of diabetes control in the setting with high prevalence of hemoglobinopathy, fructosamine is recommended.2 This should be applied for management of any patient with background origin from endemic countries such as those countries in Southeast Asia and Africa.

[学科分类] 过敏症与临床免疫学