Independent and interactive associations of season, dietary vitamin D, and vitamin D-related genetic variants with serum 25(OH)D in Korean adults aged 40 years or older

[摘要] Only limited information is available on the inter-relationships between genetic and non-genetic factors such as diet and sunlight exposure with serum 25-hydroxyvitamin D [25(OH)D] concentration. This cross-sectional study aimed to examine the independent and interactive associations of season, dietary vitamin D intake, and SNPs of 11 vitamin D-related candidate genes with serum 25(OH)D concentration among 2,721 adults aged ≥40 years at baseline from the Yangpyeong cohort, a part of the Korean Genome Epidemiology Study (KoGES). The interactions between season or dietary vitamin D and 556 SNPs were evaluated using 2-degree of freedom joint tests. Season was strongly ( p difference = 1.00 × 10 –12 ) and dietary vitamin D intake was slightly but significantly associated with serum 25(OH)D concentration ( p difference = 0.0119). Among five SNPs (rs11723621- GC , rs7041- GC , rs10500804- CYP2R1 , rs7129781- CYP2R1 , and rs2852853- DHCR7 ) identified in the screening steps, only one, rs10500804- CYP2R1 , significantly interacted with season ( p interaction = 8.01 × 10 –5 ). The inverse association between number of minor alleles of rs10500804- CYP2R1 and concentration of 25(OH)D was significant only in summer/fall. Conversely, dietary vitamin D intake was positively associated only in winter/spring. In conclusion, season, dietary vitamin D intake, and four SNPs in GC , CYP2R1 , and DHCR7 are independently and rs10500804- CYP2R1 is interactively associated with serum 25(OH)D concentration. Serum 25(OH)D is influenced by genotype of rs10500804- CYP2R1 in summer/fall when sunlight exposure is high, while dietary vitamin D intake is an important determinant of serum 25(OH)D during the seasons with low cutaneous vitamin D synthesis.

[学科分类] 内分泌与代谢学

[关键词] Vitamin D;25-Hydroxyvitamin D;Season;Dietary vitamin D intake