Troponin as a biomarker for mortality in stable COPD

[摘要] COPD is a leading cause of death in the world. COPD represents the pulmonary component of multimorbidity, often with cardiovascular disease (CVD) as the most prevalent, and possibly the most clinically relevant [1]. Indeed, cardiovascular diseases affect quality of life and healthcare costs, and are a major cause of death in COPD [2, 3]. The Global Initiative for Chronic Obstructive Lung Disease (GOLD) initiative recognises CVD as the most important disease coexisting with COPD and suggests it should be routinely looked for, suggesting the use of a CVD risk calculator [4]. Although plenty of well conducted research has been done in the past decades related to the pathophysiological connections between COPD and CVD, these are still not fully understood [5]. Smoking and inactivity are common risk factors, and the metabolic syndrome is commonly seen in COPD [6]. However, multiple variables in COPD are likely to contribute to the complexity of coexistence of cardiovascular disease and COPD. For example, enhanced systemic inflammatory response, hypoxaemia, sleep disturbances, exacerbations and lung hyperinflation, have all been put forward as contributing factors connecting both diseases.

[学科分类] 呼吸医学