Chromosomal integrity and DNA damage in freeze-dried spermatozoa

[摘要] Background: Scoliosis is a spinal deformity that often occurs in adolescents with a pre­va­lence of 0.47% -5.2% worldwide. The preva­lence of scoliosis in Asia was about 2.25% of the population. In Surabaya, Indonesia, 6.37% of students from 784 schools who con­ducted sco­liosis screening tests positively had scoliosis. In addition, 9 out of 300 students in Surakarta positively had scoliosis. This study aimed to estimate the effect of using scoliosis orthosis in reducingcobb angle in scoliosis patients by conducting a meta-analysis on theseveral similar articles. Subjects and Method: This study used a meta-analysis by systematically reviewing the several similar articles from PubMed, ScienceDirect, and Google Scholar. The key­words were "scoliosis" AND "scoliosis ortho­sis" OR "scoliosis brace" AND "cobb angle" OR "curve" AND "randomized control trial". The intervention was the use of a scoliosis orthosis with a comparison of non-scoliosis orthosis and the scoliosis patients as the study subjects. The outcome of the study was a reduction of cobb angle. The included arti­cles were full-text articles with a randomized controlled trial design that showed the effect size (mean and standard deviations). The articles were collect­ed using PRISMA flow diagrams and analyzed using the Review Manager 5.3 application. Results: Based on a meta-analysis result of 9 randomized controlled trial articles from the United States, Canada, Germany, Sweden, Denmark, Poland, and Hong Kong, scoliosis orthosis reduced cobb angle in scoliosis pati­ents (SMD= -0.67; 95% CI= -1.02 to -0.33; p <0.001). The heterogeneity I 2 =75%. Conclusion: Scoliosis orthosis affects the reduction of cobb angle in scoliosis patients.

[学科分类] 工业工程学

[关键词] Chromosome Cryopreservation DNA damage Freeze-drying Spermatozoa