What are the risks of the assisted reproductive technologies (ART) and how can they be minimized?

[摘要] Background : Hyperuricemia is an elevated serum uric acid level. It causes urate deposits in the joints, tendons, and other tissues as physiological prerequisites for gout. Hyperuricemia is also related to the existence and severity of several comorbidities, such as hypertension, cardio­vascular disease, diabetes, and metabolic syndrome. The result of basic health research in 2018 showed that the prevalence of joint disease in Indonesia based on a doctor's diagnosis was 7.3%. The highest prevalence was in Aceh (13.3%). The lowest prevalence was in West Sulawesi (3.2%). This study aimed to examine factors associated with hyperuricemia. Subje cts and Method: This was an analytical observational study with a case control design. The study was conducted in Sukoharjo, Central Java, from January to April, 2018. A sample of 90 study subjects was selected by consecutive sampling. The dependent variable was hyper­uricemia. The independent variables were age, sex, stress, purine-rich foods intake, and family history of gout. Stress was measured by depression, anxiety, and stress scale (DASS 42). The other variables were collected by questionnaire. The data were analyzed by a multiple logistic regression. Results : Older age (OR= 13.80; 95% CI= 3.36 to 56.66; p<0.001), female (OR= 1.94; 95% CI= 3.36 to 7.62; p= 0.345), purine-rich foods intake (OR= 5.01; 95% CI= 1.48 to 16.97; p= 0.010), and stress (OR= 6.14; 95% CI= 1.83 to 20.60; p= 0.003) increased the risk of hyperuricemia. Family history of gout (OR= 1.47; 95% CI= 0.43 to 5.04; p= 0.537) increased the risk of hyperuricemia, but it was statistically non-significant. Conclusion : Age, female, purine-rich foods intake, and stress increase the risk of hyper­uricemia. Family history of gout increases the risk of hyperuricemia, but it was statistically non-significant.

[学科分类] 工业工程学

[关键词] ART Embryo IVF Neonatal outcomes Risk