Design, Synthesis and Cytotoxicity Study of Primary Amides as Histone Deacetylase Inhibitors

[摘要] Primary amide derivatives as histone deacetylase inhibitors (HDACIs) are very rare. This paper describes the synthesis of the primary amide derivatives adipic monoanilide amide and pimelic monoanilide amide (compounds 6 and 7) that have the requirements to be histone deacetylase inhibitors of the zinc-binding type. Both of them exhibited good cytotoxicity against the tested cancer cell lines with much lower cytotoxicity against normal cell line.

[学科分类] 计算机网络和通讯

[关键词] Primary amides;HDACIs;Adipic monoanilide amide;Pimelic monoanilide amide