Investigation of cytotoxic activity and dissolution improvement of Teniposide by incorporation into acid treated carbon nanotube and dispersed by hydrophilic polymer

[摘要] Single walled Carbon nanotubes (SWCNT), as nano-needle structures, are good candidates as nanocarrier delivery systems that can carry drug to the site of action especially for chemotherapy. Teniposide is an anticancer drug, but it has a problem of low solubility. In this study, carbon nanotubes properties were improved by pre-functionalized of carbon nanotubes via carboxylation with strong acids and then functionalized through attaching to polymer and copolymer. Concurrently, a proper polymer-copolymer combination has been selected by the homogeneity and UV-Visible spectroscopy. The best formula (F19) is further studied utilizing Fourier transoform infra red, scanning electron microscopy, Transmittance electron microscopy, and the solubility of teniposide. The results showed that the best dispersibility obtained in the formula that used polyvinyl alcohol (PVA) as polymer and polyethylene oxide (PEO) as copolymer at a ratio of 1:1. The solubility of incorporated teniposide in the selected formula is increased by 11.5 fold. Accordingly, it can be concluded that the acid treated carbon nanotube and linked by polymer improve the pharmaceutical properties of the carrier and actively increase the potency of drug.

[学科分类] 计算机网络和通讯

[关键词] Acid treated carbon nanotubes;Teniposide;Hydrophilic polymers.