Investigation of Solubility Enhancement Approaches of Ticagrelor

[摘要] The aim of this study was to increase the solubility and enhancement of dissolution rate of poorly water-soluble drug ticagrelor this was done through formulating and evaluate ticagrelor nanoparticles using solvent antisolvent technology. Ticagrelor is a practically water-insoluble drug which acts as an antiplatelet medicine.Fifteen formulas were prepared, and different stabilizing agents were used with various concentrations such as poly vinyl pyrrolidine (PVPK-30), poloxamer 188 (PXM) and hydroxypropyl methyl cellulose (HPMC). The ratios of drug to stabilizers used to prepare the nanoparticles were 1: 0.5, 1:1 and 1:2. The prepared formulas were evaluated for the sake of particle size, dissolution study, Fourier transform infrared spectroscopy, differential scanning calorimetry, and scanning electron microscopy. On the other hand, the increasing dissolution rate as the particle surface area can be increased due to the reduction of particle size to the nano range.The results showed that hydroxy propyl methyl cellulose (HPMC) (F 12) was found to be the best stabilizer.

[学科分类] 计算机网络和通讯

[关键词] Ticagrelor;Nanoparticles;Particle Size;hydroxy propyl methyl cellulose.