EFFECTS OF STIRRING RATE AND DRUG: POLYMER RATIO ON THE CHARACTERISTICS OF LEVOBUNOLOL HCL LOADED POLY (e-CAPROLACTONE) MICROPARTICLES

[摘要] Extended-release granule formulations containing diclofenac sodium were prepared by wet granulation of Eudragit® L100 and Eudragit® NM 30D polymers. The drug release was examined in phosphate buffer (pH 6.8). The formulations allowed 100 % released drug by 720 min. The granules were evaluated with respect to their anti-inflammatory and ulcerogenic activity in rats. Eudragit® L100/Eudragit® NM 30D granules provide a significant and prolonged anti-inflammatory effect and also significantly reduce (52-74 %) the gastric lesion index.

[关键词] Stirring rate;Drugpolymer ratio;Levobunolol HCl;Poly (e-caprolactone);Microparticles